Tesamorelin Explained: the GHRH Analogue, Its Mass and How to Verify a Batch
Tesamorelin is a synthetic analogue of growth-hormone-releasing hormone (GHRH). It consists of all 44 amino acids of human GHRH with a trans-3-hexenoyl group attached to the first residue, and has a molecular mass of about 5,135.9 Da. This guide explains its structure, what the literature covers and how to verify a batch.
Key facts
- Type: Synthetic analogue of human growth-hormone-releasing hormone (GHRH)
- Sequence: Human GHRH(1–44) amide with a trans-3-hexenoyl group on the N-terminal tyrosine
- Molecular formula: C221H366N72O67S
- Molecular mass: about 5,135.9 Da
- CAS number: 218949-48-5
- Supplied as: lyophilised powder in a sealed vial
What is tesamorelin
Tesamorelin has the full sequence of human GHRH. The only change is a six-carbon trans-3-hexenoyl group on the first amino acid. That group makes the peptide more resistant to the enzyme that normally cuts GHRH at its N-terminus, so it is more stable than the natural hormone. The research material is made by chemical synthesis.
What the scientific literature covers
Published work spans cell assays, animal models and clinical trials. Laboratory topics include:
- Binding to the GHRH receptor on pituitary cells
- The cAMP signalling pathway
- The growth hormone and IGF-1 axis in animal models
- Stability of the analogue compared with natural GHRH
These are laboratory findings. CellMind supplies Tesamorelin for research purposes only, not for human use. Tesamorelin is also the active substance of an approved medicine. CellMind material is a research compound, not a medicine.
How identity and purity are verified
With 44 amino acids, tesamorelin can carry more shortened by-products than a short peptide, and its methionine residue oxidises easily. HPLC separates these from the target peptide. Mass spectrometry confirms the mass of about 5,135.9 Da. Tesamorelin is about 96 Da heavier than unmodified GHRH(1–44) amide, so the mass shows whether the hexenoyl group is present. Both results must appear on the certificate of analysis (CoA) for the specific batch. Our CoA guide explains how to read one.
Checklist before buying Tesamorelin
- A CoA for the specific batch
- HPLC purity stated as a number, above 99%
- Mass of about 5,136 Da confirmed on the report
- A clearly stated amount per vial (10 mg)
- A batch number on the vial that matches the report
Common questions about Tesamorelin
How is tesamorelin different from natural GHRH?
The amino acid sequence is the same. Tesamorelin has an added trans-3-hexenoyl group on the first residue, which makes it about 96 Da heavier and more stable against enzymatic cleavage.
How is tesamorelin different from sermorelin?
Sermorelin is the first 29 amino acids of GHRH (about 3,357.9 Da). Tesamorelin has all 44 amino acids plus the hexenoyl group (about 5,135.9 Da).
What mass should a tesamorelin report show?
About 5,135.9 Da. A value near 5,040 Da would point to unmodified GHRH.
Storage and handling
Keep lyophilised vials in a cool, dark place. After reconstitution the solution should be refrigerated and used within the planned study period. Avoid repeated temperature changes: they are the most common cause of degradation that nobody notices until results stop matching.
CellMind Tesamorelin 10mg
- 10 mg of lyophilised powder per vial, sealed under inert conditions
- HPLC-tested by Janoshik Analytical, purity above 99%
- A CoA for the specific batch with every order
Product page: Tesamorelin 10mg. Ordering and delivery: Where to buy Tesamorelin. Reports for current batches: Lab reports and CoA.
Sources
Research purposes only.